Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing

Antisense oligonucleotide (ASO)-based therapy is one of the next-generation therapy, especially targeting neurological disorders. Many cases of ASO-dependent gene expression suppression have been reported. Recently, we developed a tocopherol conjugated DNA/RNA heteroduplex oligonucleotide (Toc-HDO)...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Asada, Ken, Sakaue, Fumika, Nagata, Tetsuya, Zhang, Ji-chun, Yoshida-Tanaka, Kie, Abe, Aya, Nawa, Makiko, Nishina, Kazutaka, Yokota, Takanori
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Chemical Biology and Nucleic Acid Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8136785/
https://ncbi.nlm.nih.gov/pubmed/33928345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab258
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