Bioenergetic and inflammatory systemic phenotypes in Alzheimer’s disease APOE ε4‐carriers

We examined the impact of an APOE ε4 genotype on Alzheimer's disease (AD) subject platelet and lymphocyte metabolism. Mean platelet mitochondrial cytochrome oxidase Vmax activity was lower in APOE ε4 carriers and lymphocyte Annexin V, a marker of apoptosis, was significantly higher. Proteins th...

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Bibliografiska uppgifter
I publikationen:Aging Cell
Huvudupphovsmän: Wilkins, Heather M., Wang, Xiaowan, Menta, Blaise W., Koppel, Scott J., Bothwell, Rebecca, Becker, Annette M., Anderson, Heidi, Schwartz, Erin, Pei, Dong, Yellapu, Nanda K., Chalise, Prabhakar, Gouvion, Cynthia M., Haeri, Mohammad, Burns, Jeffrey M., Swerdlow, Russell H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2021
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135087/
https://ncbi.nlm.nih.gov/pubmed/33939248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13356
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