Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles

BACKGROUND: The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease, whilst the ε2 allele confers protection. Previous studies report differential DNA methylation of APOE between ε4 and ε2 carriers, but associations with epigenome-wide methylatio...

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Pubblicato in:Genome Med
Autori principali: Walker, Rosie M., Vaher, Kadi, Bermingham, Mairead L., Morris, Stewart W., Bretherick, Andrew D., Zeng, Yanni, Rawlik, Konrad, Amador, Carmen, Campbell, Archie, Haley, Chris S., Hayward, Caroline, Porteous, David J., McIntosh, Andrew M., Marioni, Riccardo E., Evans, Kathryn L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7784364/
https://ncbi.nlm.nih.gov/pubmed/33397400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00808-4
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