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Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles
BACKGROUND: The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease, whilst the ε2 allele confers protection. Previous studies report differential DNA methylation of APOE between ε4 and ε2 carriers, but associations with epigenome-wide methylatio...
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| Опубликовано в: : | Genome Med |
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| Главные авторы: | , , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7784364/ https://ncbi.nlm.nih.gov/pubmed/33397400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00808-4 |
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