Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles

BACKGROUND: The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease, whilst the ε2 allele confers protection. Previous studies report differential DNA methylation of APOE between ε4 and ε2 carriers, but associations with epigenome-wide methylatio...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Walker, Rosie M., Vaher, Kadi, Bermingham, Mairead L., Morris, Stewart W., Bretherick, Andrew D., Zeng, Yanni, Rawlik, Konrad, Amador, Carmen, Campbell, Archie, Haley, Chris S., Hayward, Caroline, Porteous, David J., McIntosh, Andrew M., Marioni, Riccardo E., Evans, Kathryn L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7784364/
https://ncbi.nlm.nih.gov/pubmed/33397400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00808-4
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