Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles

BACKGROUND: The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease, whilst the ε2 allele confers protection. Previous studies report differential DNA methylation of APOE between ε4 and ε2 carriers, but associations with epigenome-wide methylatio...

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Опубликовано в: :Genome Med
Главные авторы: Walker, Rosie M., Vaher, Kadi, Bermingham, Mairead L., Morris, Stewart W., Bretherick, Andrew D., Zeng, Yanni, Rawlik, Konrad, Amador, Carmen, Campbell, Archie, Haley, Chris S., Hayward, Caroline, Porteous, David J., McIntosh, Andrew M., Marioni, Riccardo E., Evans, Kathryn L.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2021
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7784364/
https://ncbi.nlm.nih.gov/pubmed/33397400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00808-4
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