Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients

A degradation product of APOE ε4-encoded apolipoprotein E protein targets mitochondria and inhibits cytochrome oxidase (COX), and autopsy brains from young adult APOE ε4 carriers show reduced COX activity. To further explore relationships between APOE alleles and COX, we measured platelet mitochondr...

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Bibliographic Details
Published in:Redox Biol
Main Authors: Wilkins, Heather M., Koppel, Scott J., Bothwell, Rebecca, Mahnken, Jonathan, Burns, Jeffrey M., Swerdlow, Russell H.
Format: Artigo
Language:Inglês
Published: Elsevier 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406545/
https://ncbi.nlm.nih.gov/pubmed/28448944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.04.010
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