Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients

A degradation product of APOE ε4-encoded apolipoprotein E protein targets mitochondria and inhibits cytochrome oxidase (COX), and autopsy brains from young adult APOE ε4 carriers show reduced COX activity. To further explore relationships between APOE alleles and COX, we measured platelet mitochondr...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Wilkins, Heather M., Koppel, Scott J., Bothwell, Rebecca, Mahnken, Jonathan, Burns, Jeffrey M., Swerdlow, Russell H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406545/
https://ncbi.nlm.nih.gov/pubmed/28448944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.04.010
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