Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients

A degradation product of APOE ε4-encoded apolipoprotein E protein targets mitochondria and inhibits cytochrome oxidase (COX), and autopsy brains from young adult APOE ε4 carriers show reduced COX activity. To further explore relationships between APOE alleles and COX, we measured platelet mitochondr...

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Gepubliceerd in:Redox Biol
Hoofdauteurs: Wilkins, Heather M., Koppel, Scott J., Bothwell, Rebecca, Mahnken, Jonathan, Burns, Jeffrey M., Swerdlow, Russell H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2017
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406545/
https://ncbi.nlm.nih.gov/pubmed/28448944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.04.010
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