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“Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
All neurodegenerative diseases feature aggregates, which usually contain disease‐specific diagnostic proteins; non‐protein constituents, however, have rarely been explored. Aggregates from SY5Y‐APP(Sw) neuroblastoma, a cell model of familial Alzheimer's disease, were crosslinked and sequences o...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8135009/ https://ncbi.nlm.nih.gov/pubmed/33788386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13326 |
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