Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans

The consequences of damage to the mitochondrial genome (mtDNA) are poorly understood, although mtDNA is more susceptible to damage resulting from some genotoxicants than nuclear DNA (nucDNA), and many environmental toxicants target the mitochondria. Reports from the toxicological literature suggest...

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Vydáno v:Redox Biol
Hlavní autoři: Hershberger, Kathleen A., Rooney, John P., Turner, Elena A., Donoghue, Lauren J., Bodhicharla, Rakesh, Maurer, Laura L., Ryde, Ian T., Kim, Jina J., Joglekar, Rashmi, Hibshman, Jonathan D., Smith, Latasha L., Bhatt, Dhaval P., Ilkayeva, Olga R., Hirschey, Matthew D., Meyer, Joel N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134077/
https://ncbi.nlm.nih.gov/pubmed/33993056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.102000
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