Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans

The consequences of damage to the mitochondrial genome (mtDNA) are poorly understood, although mtDNA is more susceptible to damage resulting from some genotoxicants than nuclear DNA (nucDNA), and many environmental toxicants target the mitochondria. Reports from the toxicological literature suggest...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Hershberger, Kathleen A., Rooney, John P., Turner, Elena A., Donoghue, Lauren J., Bodhicharla, Rakesh, Maurer, Laura L., Ryde, Ian T., Kim, Jina J., Joglekar, Rashmi, Hibshman, Jonathan D., Smith, Latasha L., Bhatt, Dhaval P., Ilkayeva, Olga R., Hirschey, Matthew D., Meyer, Joel N.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134077/
https://ncbi.nlm.nih.gov/pubmed/33993056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.102000
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