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Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone

Rotenone, a mitochondrial complex I inhibitor, has been widely used to study the effects of mitochondrial dysfunction on dopaminergic neurons in the context of Parkinson’s disease. Although the deleterious effects of rotenone are well documented, we found that young adult Caenorhabditis elegans show...

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Vydáno v:Toxicology
Hlavní autoři: Gonzalez-Hunt, Claudia P., Luz, Anthony L., Ryde, Ian T., Turner, Elena A., Ilkayeva, Olga R., Bhatt, Dhaval P., Hirschey, Matthew D., Meyer, Joel N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750303/
https://ncbi.nlm.nih.gov/pubmed/33188857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2020.152630
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