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Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone

Rotenone, a mitochondrial complex I inhibitor, has been widely used to study the effects of mitochondrial dysfunction on dopaminergic neurons in the context of Parkinson’s disease. Although the deleterious effects of rotenone are well documented, we found that young adult Caenorhabditis elegans show...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxicology
Prif Awduron: Gonzalez-Hunt, Claudia P., Luz, Anthony L., Ryde, Ian T., Turner, Elena A., Ilkayeva, Olga R., Bhatt, Dhaval P., Hirschey, Matthew D., Meyer, Joel N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750303/
https://ncbi.nlm.nih.gov/pubmed/33188857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2020.152630
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