SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

We discovered that the survival and growth of many primary acute myeloid leukemia (AML) samples and cell lines, but not normal CD34(+) cells, are dependent on SIRT5, a lysine deacylase implicated in regulating multiple metabolic pathways. Dependence on SIRT5 is genotype agnostic and extends to RAS-...

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Pubblicato in:Blood Cancer Discov
Autori principali: Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D., Halverson, Brayden J., Antelope, Orlando, Mason, Clinton C., Ahmann, Jonathan M., Senina, Anna V., Vellore, Nadeem A., Jones, Courtney L., Zabriskie, Matthew S., Than, Hein, Xiao, Michael J., van Scoyk, Alexandria, Patel, Ami B., Clair, Phillip M., Heaton, William L., Owen, Shawn C., Andersen, Joshua L., Egbert, Christina M., Reisz, Julie A., D'Alessandro, Angelo, Cox, James E., Gantz, Kevin C., Redwine, Hannah M., Iyer, Siddharth M., Khorashad, Jamshid S., Rajabi, Nima, Olsen, Christian A., O'Hare, Thomas, Deininger, Michael W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for Cancer Research 2021
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133360/
https://ncbi.nlm.nih.gov/pubmed/34027418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-20-0168
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