SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

We discovered that the survival and growth of many primary acute myeloid leukemia (AML) samples and cell lines, but not normal CD34(+) cells, are dependent on SIRT5, a lysine deacylase implicated in regulating multiple metabolic pathways. Dependence on SIRT5 is genotype agnostic and extends to RAS-...

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Detalhes bibliográficos
Publicado no:Blood Cancer Discov
Main Authors: Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D., Halverson, Brayden J., Antelope, Orlando, Mason, Clinton C., Ahmann, Jonathan M., Senina, Anna V., Vellore, Nadeem A., Jones, Courtney L., Zabriskie, Matthew S., Than, Hein, Xiao, Michael J., van Scoyk, Alexandria, Patel, Ami B., Clair, Phillip M., Heaton, William L., Owen, Shawn C., Andersen, Joshua L., Egbert, Christina M., Reisz, Julie A., D'Alessandro, Angelo, Cox, James E., Gantz, Kevin C., Redwine, Hannah M., Iyer, Siddharth M., Khorashad, Jamshid S., Rajabi, Nima, Olsen, Christian A., O'Hare, Thomas, Deininger, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133360/
https://ncbi.nlm.nih.gov/pubmed/34027418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-20-0168
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