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Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody response

The receptor binding domain (RBD) of the SARS-CoV-2 spike protein is the primary target of neutralizing antibodies and is a component of almost all vaccine candidates. Here, RBD immunogens were created with stabilizing amino acid changes that improve the neutralizing antibody response, as well as ch...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Dickey, Thayne H., Tang, Wai Kwan, Butler, Brandi, Ouahes, Tarik, Orr-Gonzalez, Sachy, Salinas, Nichole D., Lambert, Lynn E., Tolia, Niraj H.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132226/
https://ncbi.nlm.nih.gov/pubmed/34013270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.05.09.443238
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