The SARS-CoV-2 mRNA-1273 vaccine elicits more RBD-focused neutralization, but with broader antibody binding within the RBD

The emergence of SARS-CoV-2 variants with mutations in key antibody epitopes has raised concerns that antigenic evolution will erode immunity. The susceptibility of immunity to viral evolution is shaped in part by the breadth of epitopes targeted. Here we compare the specificity of antibodies elicit...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Greaney, Allison J., Loes, Andrea N., Gentles, Lauren E., Crawford, Katharine H.D., Starr, Tyler N., Malone, Keara D., Chu, Helen Y., Bloom, Jesse D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8057239/
https://ncbi.nlm.nih.gov/pubmed/33880474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.04.14.439844
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