The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors

Fused in sarcoma (FUS) is a predominantly nuclear RNA-binding protein with key functions in RNA processing and DNA damage repair. Defects in nuclear import of FUS have been linked to severe neurodegenerative diseases; hence, it is of great interest to understand this process and how it is dysregulat...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Baade, Imke, Hutten, Saskia, Sternburg, Erin L., Pörschke, Marius, Hofweber, Mario, Dormann, Dorothee, Kehlenbach, Ralph H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131929/
https://ncbi.nlm.nih.gov/pubmed/33857479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100659
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