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Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1
TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of neurons and glial cells. Defects in nucleocyt...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5935713/ https://ncbi.nlm.nih.gov/pubmed/29728564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25007-5 |
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