Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1

TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of neurons and glial cells. Defects in nucleocyt...

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Publicado en:Sci Rep
Main Authors: Ederle, Helena, Funk, Christina, Abou-Ajram, Claudia, Hutten, Saskia, Funk, Eva B. E., Kehlenbach, Ralph H., Bailer, Susanne M., Dormann, Dorothee
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935713/
https://ncbi.nlm.nih.gov/pubmed/29728564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25007-5
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