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Optogenetics-based localization of talin to the plasma membrane promotes activation of β3 integrins
Interaction of talin with the cytoplasmic tails of integrin β triggers integrin activation, leading to an increase of integrin affinity/avidity for extracellular ligands. In talin KO mice, loss of talin interaction with platelet integrin αIIbβ3 causes a severe hemostatic defect, and loss of talin in...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8131925/ https://ncbi.nlm.nih.gov/pubmed/33865854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100675 |
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