Optogenetics-based localization of talin to the plasma membrane promotes activation of β3 integrins

Interaction of talin with the cytoplasmic tails of integrin β triggers integrin activation, leading to an increase of integrin affinity/avidity for extracellular ligands. In talin KO mice, loss of talin interaction with platelet integrin αIIbβ3 causes a severe hemostatic defect, and loss of talin in...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Liao, Zhongji, Gingras, Alexandre R., Lagarrigue, Frederic, Ginsberg, Mark H., Shattil, Sanford J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131925/
https://ncbi.nlm.nih.gov/pubmed/33865854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100675
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