IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation

Regulatory T cells play a crucial role in orchestrating immune response and maintaining immune tolerance, and the expression of the Foxp3 gene is indispensable to the differentiation of regulatory T cells. IL-4 shows strong inhibitory effects on Foxp3 expression and regulatory T cells differentiatio...

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Udgivet i:Cell Death Dis
Main Authors: Cui, Jikai, Xu, Heng, Yu, Jizhang, Li, Yuan, Chen, Zhang, Zou, Yanqiang, Zhang, Xi, Du, Yifan, Xia, Jiahong, Wu, Jie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131756/
https://ncbi.nlm.nih.gov/pubmed/34006836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03769-7
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