Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

Mutations in the G protein-coupled receptor (GPCR) rhodopsin are a common cause of autosomal dominant retinitis pigmentosa, a blinding disease. Rhodopsin self-associates in the membrane, and the purified monomeric apo-protein opsin dimerizes in vitro as it transitions from detergent micelles to reco...

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Publicat a:Sci Rep
Autors principals: Khelashvili, George, Pillai, Anoop Narayana, Lee, Joon, Pandey, Kalpana, Payne, Alexander M., Siegel, Zarek, Cuendet, Michel A., Lewis, Tylor R., Arshavsky, Vadim Y., Broichhagen, Johannes, Levitz, Joshua, Menon, Anant K.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131606/
https://ncbi.nlm.nih.gov/pubmed/34006992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-90039-3
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