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The effect of mitochondrial calcium uniporter and cyclophilin D knockout on resistance of brain mitochondria to Ca(2+)-induced damage
The mitochondrial calcium uniporter (MCU) and cyclophilin D (CyD) are key players in induction of the permeability transition pore (PTP), which leads to mitochondrial depolarization and swelling, the major signs of Ca(2+)-induced mitochondrial damage. Mitochondrial depolarization inhibits ATP produc...
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| Опубликовано в: : | J Biol Chem |
|---|---|
| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8131324/ https://ncbi.nlm.nih.gov/pubmed/33864812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100669 |
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