The effect of mitochondrial calcium uniporter and cyclophilin D knockout on resistance of brain mitochondria to Ca(2+)-induced damage

The mitochondrial calcium uniporter (MCU) and cyclophilin D (CyD) are key players in induction of the permeability transition pore (PTP), which leads to mitochondrial depolarization and swelling, the major signs of Ca(2+)-induced mitochondrial damage. Mitochondrial depolarization inhibits ATP produc...

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Опубликовано в: :J Biol Chem
Главные авторы: Hamilton, James, Brustovetsky, Tatiana, Brustovetsky, Nickolay
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2021
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131324/
https://ncbi.nlm.nih.gov/pubmed/33864812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100669
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