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The effect of mitochondrial calcium uniporter and cyclophilin D knockout on resistance of brain mitochondria to Ca(2+)-induced damage

The mitochondrial calcium uniporter (MCU) and cyclophilin D (CyD) are key players in induction of the permeability transition pore (PTP), which leads to mitochondrial depolarization and swelling, the major signs of Ca(2+)-induced mitochondrial damage. Mitochondrial depolarization inhibits ATP produc...

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Pubblicato in:J Biol Chem
Autori principali: Hamilton, James, Brustovetsky, Tatiana, Brustovetsky, Nickolay
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131324/
https://ncbi.nlm.nih.gov/pubmed/33864812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100669
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