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Mutant Huntingtin Fails to Directly Impair Brain Mitochondria
Although the mechanisms by which mutant huntingtin (mHtt) results in Huntington’s disease (HD) remain unclear, mHtt-induced mitochondrial defects were implicated in HD pathogenesis. The effect of mHtt could be mediated by transcriptional alterations, by direct interaction with mitochondria, or by bo...
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| Publicado no: | J Neurochem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6917837/ https://ncbi.nlm.nih.gov/pubmed/31418857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14852 |
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