Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

Virus propagation methods generally use transformed cell lines to grow viruses from clinical specimens, which may force viruses to rapidly adapt to cell culture conditions, a process facilitated by high viral mutation rates. Upon propagation in VeroE6 cells, SARS-CoV-2 may mutate or delete the multi...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Lamers, Mart M, Mykytyn, Anna Z, Breugem, Tim I, Wang, Yiquan, Wu, Douglas C, Riesebosch, Samra, van den Doel, Petra B, Schipper, Debby, Bestebroer, Theo, Wu, Nicholas C, Haagmans, Bart L
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2021
Matèries:
Microbiology and Infectious Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131099/
https://ncbi.nlm.nih.gov/pubmed/33835028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66815
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