Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

Virus propagation methods generally use transformed cell lines to grow viruses from clinical specimens, which may force viruses to rapidly adapt to cell culture conditions, a process facilitated by high viral mutation rates. Upon propagation in VeroE6 cells, SARS-CoV-2 may mutate or delete the multi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:eLife
Päätekijät: Lamers, Mart M, Mykytyn, Anna Z, Breugem, Tim I, Wang, Yiquan, Wu, Douglas C, Riesebosch, Samra, van den Doel, Petra B, Schipper, Debby, Bestebroer, Theo, Wu, Nicholas C, Haagmans, Bart L
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: eLife Sciences Publications, Ltd 2021
Aiheet:
Microbiology and Infectious Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131099/
https://ncbi.nlm.nih.gov/pubmed/33835028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66815
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