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Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

Virus propagation methods generally use transformed cell lines to grow viruses from clinical specimens, which may force viruses to rapidly adapt to cell culture conditions, a process facilitated by high viral mutation rates. Upon propagation in VeroE6 cells, SARS-CoV-2 may mutate or delete the multi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lamers, Mart M, Mykytyn, Anna Z, Breugem, Tim I, Wang, Yiquan, Wu, Douglas C, Riesebosch, Samra, van den Doel, Petra B, Schipper, Debby, Bestebroer, Theo, Wu, Nicholas C, Haagmans, Bart L
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131099/
https://ncbi.nlm.nih.gov/pubmed/33835028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66815
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