SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in vivo. A remarkable feature of the severe acute resp...

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Udgivet i:eLife
Main Authors: Mykytyn, Anna Z, Breugem, Tim I, Riesebosch, Samra, Schipper, Debby, van den Doel, Petra B, Rottier, Robbert J, Lamers, Mart M, Haagmans, Bart L
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2021
Fag:
Microbiology and Infectious Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806259/
https://ncbi.nlm.nih.gov/pubmed/33393462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64508
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