SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in vivo. A remarkable feature of the severe acute resp...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Mykytyn, Anna Z, Breugem, Tim I, Riesebosch, Samra, Schipper, Debby, van den Doel, Petra B, Rottier, Robbert J, Lamers, Mart M, Haagmans, Bart L
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2021
Gaiak:
Microbiology and Infectious Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806259/
https://ncbi.nlm.nih.gov/pubmed/33393462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64508
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