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Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1

Human tyrosinase (hTYR) and tyrosinase-related protein 1 (hTYRP1) are closely-related enzymes involved in the synthesis of melanin, which are selectively expressed in melanocytes and, in a pathological context, in melanoma lesions. We used a previously described tyrosinase inhibitor (Thiamidol™) and...

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Bibliografski detalji
Izdano u:RSC Med Chem
Glavni autori: Catalano, Marco, Bassi, Gabriele, Rotondi, Giulia, Khettabi, Lyna, Dichiara, Maria, Murer, Patrizia, Scheuermann, Jörg, Soler-Lopez, Montserrat, Neri, Dario
Format: Artigo
Jezik:Inglês
Izdano: RSC 2020
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8130610/
https://ncbi.nlm.nih.gov/pubmed/34041485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00310g
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