Oncolytic reovirus (pelareorep) induces autophagy in KRAS-mutated colorectal cancer

PURPOSE: To explore the effects of pelareorep on autophagy in multiple models of CRC, including patient derived PBMC. EXPERIMENTAL DESIGN: HCT116 (KRAS-Mut) and Hke3 (KRAS-WT) cells were treated with pelareorep (5MOI) and harvested at 6 and 9 hours. LC3A/B expression was determined by immunofluoresc...

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Bibliografiska uppgifter
I publikationen:Clin Cancer Res
Huvudupphovsmän: Jiffry, Jeeshan, Thavornwatanayong, Thongthai, Rao, Devika, Fogel, Elisha, Saytoo, Durvanand, Nahata, Rishika, Guzik, Hillary, Chaudhary, Imran, Augustine, Titto, Goel, Sanjay, Maitra, Radhashree
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8130598/
https://ncbi.nlm.nih.gov/pubmed/33168658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2385
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