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Oncolytic reovirus (pelareorep) induces autophagy in KRAS-mutated colorectal cancer
PURPOSE: To explore the effects of pelareorep on autophagy in multiple models of CRC, including patient derived PBMC. EXPERIMENTAL DESIGN: HCT116 (KRAS-Mut) and Hke3 (KRAS-WT) cells were treated with pelareorep (5MOI) and harvested at 6 and 9 hours. LC3A/B expression was determined by immunofluoresc...
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| Publicado no: | Clin Cancer Res |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8130598/ https://ncbi.nlm.nih.gov/pubmed/33168658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2385 |
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