Development and Characterization of a Genetic Mouse Model of KRAS Mutated Colorectal Cancer

Patients with KRAS mutated colorectal cancer (CRC) represent a cohort with unmet medical needs, with limited options of FDA-approved therapies. Representing 40–45% of all CRC patients, they are considered ineligible to receive anti-EGFR monoclonal antibodies that have added a significant therapeutic...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Maitra, Radhashree, Thavornwatanayong, Thongthai, Venkatesh, Madhu Kumar, Chandy, Carol, Vachss, Dov, Augustine, Titto, Guzik, Hillary, Koba, Wade, Liu, Qiang, Goel, Sanjay
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888417/
https://ncbi.nlm.nih.gov/pubmed/31766149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20225677
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