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Immune characterization of metastatic colorectal cancer patients post reovirus administration

BACKGROUND: KRAS mutations are prevalent in 40–45% of patients with colorectal cancer (CRC) and targeting this gene has remained elusive. Viruses are well known immune sensitizing agents. The therapeutic efficacy of oncolytic reovirus in combination with chemotherapy is examined in a phase 1 study o...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Parakrama, Ruwan, Fogel, Elisha, Chandy, Carol, Augustine, Titto, Coffey, Matt, Tesfa, Lydia, Goel, Sanjay, Maitra, Radhashree
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301987/
https://ncbi.nlm.nih.gov/pubmed/32552875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07038-2
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