Immune characterization of metastatic colorectal cancer patients post reovirus administration

BACKGROUND: KRAS mutations are prevalent in 40–45% of patients with colorectal cancer (CRC) and targeting this gene has remained elusive. Viruses are well known immune sensitizing agents. The therapeutic efficacy of oncolytic reovirus in combination with chemotherapy is examined in a phase 1 study o...

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Vydáno v:BMC Cancer
Hlavní autoři: Parakrama, Ruwan, Fogel, Elisha, Chandy, Carol, Augustine, Titto, Coffey, Matt, Tesfa, Lydia, Goel, Sanjay, Maitra, Radhashree
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301987/
https://ncbi.nlm.nih.gov/pubmed/32552875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07038-2
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