Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan

Reovirus is a double stranded RNA virus, with an intrinsic preference for replication in KRAS mutant cells. As 45% of human colorectal cancers (CRC) harbor KRAS mutations, we sought to investigate its efficacy in KRAS mutant CRC cells, and examine its impact in combination with the topoisimerase-1 i...

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Bibliografiske detaljer
Main Authors: Maitra, Radhashree, Seetharam, Raviraja, Tesfa, Lydia, Augustine, Titto A., Klampfer, Lidija, Coffey, Matthew C., Mariadason, John M., Goel, Sanjay
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058046/
https://ncbi.nlm.nih.gov/pubmed/24798549
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