Rab40–Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration

Rab40b is a SOCS box–containing protein that regulates the secretion of MMPs to facilitate extracellular matrix remodeling during cell migration. Here, we show that Rab40b interacts with Cullin5 via the Rab40b SOCS domain. We demonstrate that loss of Rab40b–Cullin5 binding decreases cell motility an...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Biol
Prif Awduron: Linklater, Erik S., Duncan, Emily D., Han, Ke-Jun, Kaupinis, Algirdas, Valius, Mindaugas, Lyons, Traci R., Prekeris, Rytis
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Rockefeller University Press 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129794/
https://ncbi.nlm.nih.gov/pubmed/33999101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202008060
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg