Rab40–Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration

Rab40b is a SOCS box–containing protein that regulates the secretion of MMPs to facilitate extracellular matrix remodeling during cell migration. Here, we show that Rab40b interacts with Cullin5 via the Rab40b SOCS domain. We demonstrate that loss of Rab40b–Cullin5 binding decreases cell motility an...

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Bibliografske podrobnosti
izdano v:J Cell Biol
Main Authors: Linklater, Erik S., Duncan, Emily D., Han, Ke-Jun, Kaupinis, Algirdas, Valius, Mindaugas, Lyons, Traci R., Prekeris, Rytis
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129794/
https://ncbi.nlm.nih.gov/pubmed/33999101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202008060
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