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Kinetics of HTT lowering in brain of YAC 128 mice following single and repetitive intranasal dosing of siRNA packaged in chitosan-based nanoparticle
This report describes the kinetics of Huntington’s Disease (HD) gene (HTT) lowering in brains of YAC 128 mice. Lowering (or “knock-down”) of HTT mRNA expression was achieved by intranasal administration of specially designed siRNA loaded into chitosan nanoparticles. Kinetic patterns of HTT lowering...
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| Publicado en: | J Drug Deliv Sci Technol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8128136/ https://ncbi.nlm.nih.gov/pubmed/34012478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jddst.2021.102517 |
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