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Enriched Chitosan Nanoparticles Loaded with siRNA are Effective in Lowering Huntington’s Disease Gene Expression Following Intranasal Administration
Therapies to lower gene expression in brain disease currently require chronic administration into the cerebrospinal fluid (CSF) by intrathecal infusions or direct intracerebral injections. Though well-tolerated in the short-term, this approach is not tenable for a life-time of administration. Nose-t...
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| Publicado no: | Nanomedicine |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7098382/ https://ncbi.nlm.nih.gov/pubmed/31666200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2019.102119 |
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