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Enriched Chitosan Nanoparticles Loaded with siRNA are Effective in Lowering Huntington’s Disease Gene Expression Following Intranasal Administration

Therapies to lower gene expression in brain disease currently require chronic administration into the cerebrospinal fluid (CSF) by intrathecal infusions or direct intracerebral injections. Though well-tolerated in the short-term, this approach is not tenable for a life-time of administration. Nose-t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nanomedicine
Prif Awduron: Sava, Vasyl, Fihurka, Oksana, Khvorova, Anastasia, Sanchez-Ramos, Juan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098382/
https://ncbi.nlm.nih.gov/pubmed/31666200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2019.102119
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