Exposure time versus cytotoxicity for anticancer agents

PURPOSE: Time is a critical factor in drug action. The duration of inhibition of the target or residence time of the drug molecule on the target often guides drug scheduling. METHODS: The effects of time on the concentration-dependent cytotoxicity of approved and investigational agents [300 compound...

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Publicado en:Cancer Chemother Pharmacol
Main Authors: Evans, David M., Fang, Jianwen, Silvers, Thomas, Delosh, Rene, Laudeman, Julie, Ogle, Chad, Reinhart, Russell, Selby, Michael, Bowles, Lori, Connelly, John, Harris, Erik, Krushkal, Julia, Rubinstein, Larry, Doroshow, James H., Teicher, Beverly A.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127868/
https://ncbi.nlm.nih.gov/pubmed/31102023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-019-03863-w
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