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Exposure time versus cytotoxicity for anticancer agents

PURPOSE: Time is a critical factor in drug action. The duration of inhibition of the target or residence time of the drug molecule on the target often guides drug scheduling. METHODS: The effects of time on the concentration-dependent cytotoxicity of approved and investigational agents [300 compound...

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Publicat a:Cancer Chemother Pharmacol
Autors principals: Evans, David M., Fang, Jianwen, Silvers, Thomas, Delosh, Rene, Laudeman, Julie, Ogle, Chad, Reinhart, Russell, Selby, Michael, Bowles, Lori, Connelly, John, Harris, Erik, Krushkal, Julia, Rubinstein, Larry, Doroshow, James H., Teicher, Beverly A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127868/
https://ncbi.nlm.nih.gov/pubmed/31102023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-019-03863-w
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