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Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer

Enhancer of Zeste Homologue 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) that is critical for determining cell identity. An epigenetic writer, EZH2 has a well-defined role in transcriptional repression by depositing trimethyl marks on lysine 27 of histone H3. However...

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Pubblicato in:Am J Pathol
Autori principali: Anwar, Talha, Gonzalez, Maria E., Kleer, Celina G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127103/
https://ncbi.nlm.nih.gov/pubmed/33556366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2021.01.013
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