Histone chaperone CAF‐1 promotes HIV‐1 latency by leading the formation of phase‐separated suppressive nuclear bodies

HIV‐1 latency is a major obstacle to achieving a functional cure for AIDS. Reactivation of HIV‐1‐infected cells followed by their elimination via immune surveillance is one proposed strategy for eradicating the viral reservoir. However, current latency‐reversing agents (LRAs) show high toxicity and...

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Vydáno v:EMBO J
Hlavní autoři: Ma, Xiancai, Chen, Tao, Peng, Zhilin, Wang, Ziwen, Liu, Jun, Yang, Tao, Wu, Liyang, Liu, Guangyan, Zhou, Mo, Tong, Muye, Guan, Yuanjun, Zhang, Xu, Lin, Yingtong, Tang, Xiaoping, Li, Linghua, Tang, Zhonghui, Pan, Ting, Zhang, Hui
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126954/
https://ncbi.nlm.nih.gov/pubmed/33739466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106632
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