Tau forms oligomeric complexes on microtubules that are distinct from tau aggregates

Tau is a microtubule-associated protein, which promotes neuronal microtubule assembly and stability. Accumulation of tau into insoluble aggregates known as neurofibrillary tangles (NFTs) is a pathological hallmark of several neurodegenerative diseases. The current hypothesis is that small, soluble o...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gyparaki, Melina Theoni, Arab, Arian, Sorokina, Elena M., Santiago-Ruiz, Adriana N., Bohrer, Christopher H., Xiao, Jie, Lakadamyali, Melike
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126857/
https://ncbi.nlm.nih.gov/pubmed/33952699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021461118
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