Galectin-3 N-terminal tail prolines modulate cell activity and glycan-mediated oligomerization/phase separation

Galectin-3 (Gal-3) has a long, aperiodic, and dynamic proline-rich N-terminal tail (NT). The functional role of the NT with its numerous prolines has remained enigmatic since its discovery. To provide some resolution to this puzzle, we individually mutated all 14 NT prolines over the first 68 residu...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Zhao, Zihan, Xu, Xuejiao, Cheng, Hairong, Miller, Michelle C., He, Zhen, Gu, Hongming, Zhang, Zhongyu, Raz, Avraham, Mayo, Kevin H., Tai, Guihua, Zhou, Yifa
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126832/
https://ncbi.nlm.nih.gov/pubmed/33952698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021074118
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