Galectin-3 N-terminal tail prolines modulate cell activity and glycan-mediated oligomerization/phase separation

Galectin-3 (Gal-3) has a long, aperiodic, and dynamic proline-rich N-terminal tail (NT). The functional role of the NT with its numerous prolines has remained enigmatic since its discovery. To provide some resolution to this puzzle, we individually mutated all 14 NT prolines over the first 68 residu...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Zhao, Zihan, Xu, Xuejiao, Cheng, Hairong, Miller, Michelle C., He, Zhen, Gu, Hongming, Zhang, Zhongyu, Raz, Avraham, Mayo, Kevin H., Tai, Guihua, Zhou, Yifa
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2021
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126832/
https://ncbi.nlm.nih.gov/pubmed/33952698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021074118
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