Hindbrain neuropore tissue geometry determines asymmetric cell-mediated closure dynamics in mouse embryos

Gap closure is a common morphogenetic process. In mammals, failure to close the embryonic hindbrain neuropore (HNP) gap causes fatal anencephaly. We observed that surface ectoderm cells surrounding the mouse HNP assemble high-tension actomyosin purse strings at their leading edge and establish the i...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Maniou, Eirini, Staddon, Michael F., Marshall, Abigail R., Greene, Nicholas D. E., Copp, Andrew J., Banerjee, Shiladitya, Galea, Gabriel L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126771/
https://ncbi.nlm.nih.gov/pubmed/33941697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023163118
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