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Refinement of inducible gene deletion in embryos of pregnant mice

CreERT2‐mediated gene recombination is widely applied in developmental biology research. Activation of CreERT2 is typically achieved by injection of tamoxifen in an oily vehicle into the peritoneal cavity of mid‐gestation pregnant mice. This can be technically challenging and adversely impacts welfa...

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Dettagli Bibliografici
Pubblicato in:Birth Defects Res
Autori principali: Savery, Dawn, Maniou, Eirini, Culshaw, Lucy H., Greene, Nicholas D. E., Copp, Andrew J., Galea, Gabriel L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Inc. 2019
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003956/
https://ncbi.nlm.nih.gov/pubmed/31793758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdr2.1628
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