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Rho kinase-dependent apical constriction counteracts M-phase apical expansion to enable mouse neural tube closure

Cellular generation of mechanical forces required to close the presumptive spinal neural tube, the ‘posterior neuropore’ (PNP), involves interkinetic nuclear migration (INM) and apical constriction. Both processes change the apical surface area of neuroepithelial cells, but how they are biomechanica...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Butler, Max B., Short, Nina E., Maniou, Eirini, Alexandre, Paula, Greene, Nicholas D. E., Copp, Andrew J., Galea, Gabriel L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633395/
https://ncbi.nlm.nih.gov/pubmed/31182644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.230300
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