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Valproic acid disrupts the biomechanics of late spinal neural tube closure in mouse embryos
Failure of neural tube closure in the early embryo causes neural tube defects including spina bifida. Spina bifida lesions predominate in the distal spine, particularly after exposure to the anticonvulsant valproic acid (VPA). How VPA specifically disturbs late stages of neural tube closure is uncle...
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| Publicado no: | Mech Dev |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5846844/ https://ncbi.nlm.nih.gov/pubmed/29225143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mod.2017.12.001 |
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