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Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos
Human mutations in the planar cell polarity component VANGL2 are associated with the neural tube defect spina bifida. Homozygous Vangl2 mutation in mice prevents initiation of neural tube closure, precluding analysis of its subsequent roles in neurulation. Spinal neurulation involves rostral-to-caud...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Dis Model Mech |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The Company of Biologists Ltd
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5897727/ https://ncbi.nlm.nih.gov/pubmed/29590636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.032219 |
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