Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos

Human mutations in the planar cell polarity component VANGL2 are associated with the neural tube defect spina bifida. Homozygous Vangl2 mutation in mice prevents initiation of neural tube closure, precluding analysis of its subsequent roles in neurulation. Spinal neurulation involves rostral-to-caud...

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Bibliografske podrobnosti
izdano v:Dis Model Mech
Main Authors: Galea, Gabriel L., Nychyk, Oleksandr, Mole, Matteo A., Moulding, Dale, Savery, Dawn, Nikolopoulou, Evanthia, Henderson, Deborah J., Greene, Nicholas D. E., Copp, Andrew J.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897727/
https://ncbi.nlm.nih.gov/pubmed/29590636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.032219
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