Neonatal T Helper 17 Responses Are Skewed Towards an Immunoregulatory Interleukin-22 Phenotype

Newborns are frequently affected by mucocutaneous candidiasis. Th17 cells essentially limit mucosal invasion by commensal Candida spp. Here, we sought to understand the molecular basis for the developmental lack of Th17 cell responses in circulating blood neonatal T cells. Naive cord blood CD4 T cel...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Razzaghian, Hamid R., Sharafian, Zohreh, Sharma, Ashish A., Boyce, Guilaine K., Lee, Kelsey, Da Silva, Rachel, Orban, Paul C., Sekaly, Rafick-Pierre, Ross, Colin J., Lavoie, Pascal M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126652/
https://ncbi.nlm.nih.gov/pubmed/34012439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.655027
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