Neonatal T Helper 17 Responses Are Skewed Towards an Immunoregulatory Interleukin-22 Phenotype

Newborns are frequently affected by mucocutaneous candidiasis. Th17 cells essentially limit mucosal invasion by commensal Candida spp. Here, we sought to understand the molecular basis for the developmental lack of Th17 cell responses in circulating blood neonatal T cells. Naive cord blood CD4 T cel...

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Pubblicato in:Front Immunol
Autori principali: Razzaghian, Hamid R., Sharafian, Zohreh, Sharma, Ashish A., Boyce, Guilaine K., Lee, Kelsey, Da Silva, Rachel, Orban, Paul C., Sekaly, Rafick-Pierre, Ross, Colin J., Lavoie, Pascal M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126652/
https://ncbi.nlm.nih.gov/pubmed/34012439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.655027
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