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Molecular Mechanism of Small-Molecule Inhibitors in Blocking the PD-1/PD-L1 Pathway through PD-L1 Dimerization

Programmed cell death-1 (PD-1), which is a molecule involved in the inhibitory signal in the immune system and is important due to blocking of the interactions between PD-1 and programmed cell death ligand-1 (PD-L1), has emerged as a promising immunotherapy for treating cancer. In this work, molecul...

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Pubblicato in:Int J Mol Sci
Autori principali: Guo, Yan, Jin, Yulong, Wang, Bingfeng, Liu, Boping
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8125578/
https://ncbi.nlm.nih.gov/pubmed/33946261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22094766
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