Co-Targeting PIM Kinase and PI3K/mTOR in NSCLC

SIMPLE SUMMARY: PIM kinases interact with major oncogenic players, including the PI3K/Akt pathway, and provide an escape mechanism leading to drug resistance. This study examined PIM kinase expression in NSCLC and the potential of PIM1 as a prognostic marker. The effect on cell signaling of novel pr...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Moore, Gillian, Lightner, Clara, Elbai, Samira, Brady, Lauren, Nicholson, Siobhan, Ryan, Ronan, O’Sullivan, Katie E., O’Byrne, Kenneth J., Blanco-Aparicio, Carmen, Cuffe, Sinead, O’Neill, Michael, Heavey, Susan, Finn, Stephen P., Gately, Kathy
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8125027/
https://ncbi.nlm.nih.gov/pubmed/33946744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13092139
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